Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation.
Nat Rev Mol Cell Biol
; 13(5): 312-21, 2012 04 23.
Article
em En
| MEDLINE
| ID: mdl-22522719
ABSTRACT
O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the epigenetic regulation of gene expression. The enzymes involved in O-linked ß-D-N-acetylglucosamine (O-GlcNAc) cycling - O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) - target key transcriptional and epigenetic regulators including RNA polymerase II, histones, histone deacetylase complexes and members of the Polycomb and Trithorax groups. Thus, O-GlcNAc cycling may serve as a homeostatic mechanism linking nutrient availability to higher-order chromatin organization. In response to nutrient availability, O-GlcNAcylation is poised to influence X chromosome inactivation and genetic imprinting, as well as embryonic development. The wide range of physiological functions regulated by O-GlcNAc cycling suggests an unexplored nexus between epigenetic regulation in disease and nutrient availability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
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Processamento de Proteína Pós-Traducional
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Estado Nutricional
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Epigênese Genética
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article