Effect of breast cyst fluid on oestrogen 17-oxidoreductase activity in MCF-7 breast cancer cells.
Cancer Lett
; 55(2): 165-9, 1990 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-2265417
ABSTRACT
Breast cyst fluid (BCF) was found to stimulate oestrogen 17-oxidoreductase activity in the reductive direction, i.e., conversion of oestrone (E1) to oestradiol (E2), in MCF-7 breast cancer cells. Dialysis of BCF revealed that this property of BCF was present in both dialysed BCF and dialysate, implying that both high and low mol. wt. substances were responsible for stimulating E1 to E2 conversion. Gel filtration of dialysed BCF revealed that the high mol. wt. substances responsible for the stimulation of E1 to E2 conversion had mol. wts. of approximately 11 kD and 68 kD. This property of BCF would serve to increase the concentration of E2, a steroid which may play a role in mammary carcinogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Estradiol Desidrogenases
/
Doença da Mama Fibrocística
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article