[Closed-chest porcine model is superior in intervention studies of ischaemia reperfusion injury]. / Closed-chest-grisemodellen er overlegen ved interventionsstudier af iskæmireperfusionsskade.

ABSTRACT

Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.