Iron catalyzed asymmetric oxyamination of olefins.
J Am Chem Soc
; 134(30): 12370-3, 2012 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-22793789
ABSTRACT
The regioselective and enantioselective oxyamination of alkenes with N-sulfonyl oxaziridines is catalyzed by a novel iron(II) bis(oxazoline) complex. This process affords oxazolidine products that can be easily manipulated to yield highly enantioenriched free amino alcohols. The regioselectivity of this process is complementary to that obtained from the analogous copper(II)-catalyzed reaction. Thus, both regioisomers of enantioenriched 1,2-aminoalcohols can be obtained using oxaziridine-mediated oxyamination reactions, and the overall sense of regiochemistry can be controlled using the appropriate choice of inexpensive first-row transition metal catalyst.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aziridinas
/
Compostos Ferrosos
/
Alcenos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article