[Alpha-glucosidase inhibitory active constituents contained in nutshell of Trapa acornis].
Zhongguo Zhong Yao Za Zhi
; 37(10): 1408-11, 2012 May.
Article
em Zh
| MEDLINE
| ID: mdl-22860451
ABSTRACT
OBJECTIVE:
To study chemical constituents in nutshell of Trapa acornis and in vitro inhibitory activity against alpha-glucosidase.METHOD:
EtOAC and n-butanol extractive fractions were separated by chromatography and their structures were identified by multiple spectroscopic techniques.RESULT:
Nine compounds were separated, they were 4,23,24-trimethylcholest-22-en-3-ol (1), stigmasterol (2), alpha-amyrin (3), (+)-nyasol (4), oleanolic acid (5), ursolic acid (6), hederagenin (7), 3,23-dihydroxy-12-ursen-28-oic acid (8) and beta-daucosterol (9). Total extracts from T. acornis nutshells, petroleum ether fractions, acetic ether fractions and normal butanol fractions showed inhibitory activity against alpha-glucosidase. Compound 5 (IC50 2.88 mg x L(-1)) and 6 (IC50 4.42 mg L(-1)) showed stronger inhibitory activity against alpha-glucosidase.CONCLUSION:
All compounds except compound 2 were separated from the genus for the first time, and compound 1-9 were separated from this plant for the first time.
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Base de dados:
MEDLINE
Assunto principal:
Lythraceae
/
Inibidores Enzimáticos
/
Inibidores de Glicosídeo Hidrolases
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article