Facial skin barrier function recovery after microneedle transdermal delivery treatment.
Dermatol Surg
; 38(11): 1816-22, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22882208
ABSTRACT
BACKGROUND:
Microneedle treatment is currently used in the cosmetic industry for several skin conditions. Despite their extensive use, there is lack of sufficient data on the safety of microneedles.OBJECTIVE:
To investigate the degree of acute skin damage and the time required for facial skin barrier function to recover using different microneedle lengths and numbers of applications. MATERIALS ANDMETHODS:
Each side of a volunteer's face was randomly treated with one of the following treatments five applications of 0.15-mm microneedles, five applications of 0.25-mm microneedles, 10 applications of 0.15-mm microneedles, or 10 applications of 0.25-mm microneedles. Transepidermal water loss, stratum corneum hydration, and skin erythema were measured at baseline, immediately after treatment, 4 hours after treatment, and 8 hours after treatment and at 24-hour intervals for 3 days.RESULTS:
Prompt recovery of barrier function (within 72 hours) was observed after microneedle treatment.CONCLUSION:
Microneedle treatment is simple and inexpensive, and the skin barrier disruption it causes resolves quickly. Therefore, it can serve as an effective physical method of enhancing transdermal delivery of medications for the treatment of many cosmetic and dermatological conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenômenos Fisiológicos da Pele
/
Sistemas de Liberação de Medicamentos
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Face
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Microinjeções
/
Agulhas
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article