Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of Trichinella spiralis infection.
Chemotherapy
; 58(4): 295-8, 2012.
Article
em En
| MEDLINE
| ID: mdl-23075539
ABSTRACT
BACKGROUND:
Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic compound. The parent FLBZ is metabolized to its reduced (R-FLBZ) and hydrolyzed (H-FLBZ) metabolites. There are no data on the potential nematodicidal activity of R-FLBZ, the main plasma metabolite found in sheep and mice. The goal of the current work was to assess the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in a mouse model.METHODS:
Both compounds were administered to Balb/c mice infected with T. spiralis as either a cyclodextrin aqueous solution or as a carboxymethylcellulose suspension. Treatments were performed orally (5 mg/kg) at 1 day after infection with T. spiralis. The efficacy of the treatments was assessed at day 6 after infection.RESULTS:
While the efficacy obtained for FLBZ and R-FLBZ administered as a solution was 94 and 98%, respectively, the efficacies obtained after the treatment with FLBZ suspensions were 38% (FLBZ) and 64% (R-FLBZ).CONCLUSION:
Under the current experimental conditions, a high nematodicidal efficacy of both FLBZ and R-FLBZ administered as solution preparations was observed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triquinelose
/
Trichinella spiralis
/
Mebendazol
/
Anti-Helmínticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article