Long-term effect of antiangiogenic therapy for retinopathy of prematurity up to 5 years of follow-up.
Retina
; 33(2): 329-38, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23099498
ABSTRACT
PURPOSE:
To evaluate ocular function and systemic development in premature infants treated with intravitreal bevacizumab injections for retinopathy of prematurity over a period of 5 years.METHODS:
A prospective, interventional, noncomparative case study. The primary outcome measure was visual acuity. The secondary outcomes were structural assessment, other ocular functional measurements, and developmental state.RESULTS:
Eighteen eyes of 13 consecutive patients were divided into 3 groups Group 1, Stage 4 unresponsive to previous conventional treatment (n = 4); Group 2, in which conventional treatment was difficult or impossible because of inadequate visualization of the retina (n = 5); and Group 3, newly diagnosed high-risk prethreshold or threshold retinopathy of prematurity (n = 9). All patients showed initial regression of neovascularization. One patient was diagnosed with recurrence of neovascularization and was treated with intravitreal bevacizumab. Visual acuity was preserved, and median vision was 20/25 (excluding 2 operated eyes). Twelve eyes developed mainly low myopia over the years, with an overall mean value of 3.2 diopters. Electroretinograph was normal in 4 eyes that had no previous detachment. One patient showed delay in growth and neurodevelopment, whereas all the others were within the normal range.CONCLUSION:
Five years of follow-up in a small series suggest that intravitreal bevacizumab for retinopathy of prematurity results in apparently preserved ocular function and systemic development.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retinopatia da Prematuridade
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Inibidores da Angiogênese
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Fator A de Crescimento do Endotélio Vascular
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Anticorpos Monoclonais Humanizados
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article