An asymmetric synthesis of trans-fused butyrolactones from endoperoxides.
J Org Chem
; 78(7): 3476-81, 2013 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-23464745
ABSTRACT
The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peróxidos
/
4-Butirolactona
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article