CoupTFI interacts with retinoic acid signaling during cortical development.
PLoS One
; 8(3): e58219, 2013.
Article
em En
| MEDLINE
| ID: mdl-23472160
ABSTRACT
We examined the role of the orphan nuclear hormone receptor CoupTFI in mediating cortical development downstream of meningeal retinoic acid signaling. CoupTFI is a regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems. To examine the interaction of CoupTFI and cortical RA signaling we utilized Foxc1-mutant mice in which defects in meningeal development lead to alterations in cortical development due to a reduction of RA signaling. By analyzing CoupTFI(-/-);Foxc1(H/L) double mutant mice we provide evidence that CoupTFI is required for RA rescue of the ventricular zone and the neurogenic phenotypes in Foxc1-mutants. We also found that overexpression of CoupTFI in Foxc1-mutants is sufficient to rescue the Foxc1-mutant cortical phenotype in part. These results suggest that CoupTFI collaborates with RA signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Córtex Cerebral
/
Regulação da Expressão Gênica no Desenvolvimento
/
Fator I de Transcrição COUP
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article