Pregnancy disorders leading to very preterm birth influence neonatal outcomes: results of the population-based ACTION cohort study.
Pediatr Res
; 73(6): 794-801, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23493168
ABSTRACT
BACKGROUND:
We examined the relationships between -pregnancy disorders leading to very preterm birth -(spontaneous preterm labor, prelabor premature rupture of -membranes (PPROM), hypertension/preeclampsia, -intrauterine growth restriction (IUGR), antenatal hemorrhage, and maternal -infection), both in isolation and grouped together as -"disorders of placentation" (hypertensive disorders and IUGR) vs. -"presumed infection/inflammation" (all the others), and several unfavorable neonatal outcomes.METHODS:
We examined a population-based prospective cohort of 2,085 singleton infants of 23-31 wk gestational age (GA) born in six Italian regions (the Accesso alle Cure e Terapie Intensive Ostetriche e Neonatali (ACTION) study).RESULTS:
Neonates born following disorders of placentation had a higher GA and better overall outcomes than those born following infection/inflammation. After adjustment for GA, however, they showed higher risk of mortality (odds ratio, OR 1.4; 95% confidence interval, CI 1.0-2.0), bronchopulmonary dysplasia (BPD) (OR 2.5; CI 1.8-3.6), and retinopathy of prematurity (ROP) (OR 2.0; CI 1.1-3.5), especially in growth-restricted infants, and a lower risk of intraventricular hemorrhage (IVH) (OR 0.5; CI 0.3-0.8) and periventricular leukomalacia (PVL) (OR 0.6; CI 0.4-1.1) as compared with infants born following -infection/inflammation disorders.CONCLUSION:
Our data confirm the hypothesis that, in very preterm infants, adverse outcomes are both a function of immaturity (low GA) and of complications leading to preterm birth. The profile of risk is different in different pregnancy disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Resultado da Gravidez
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article