Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease.
Eur J Clin Invest
; 43(5): 501-9, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23517338
ABSTRACT
The chemokine CXCL13 has a key role in secondary lymphoid tissue orchestration and lymphoid neogenesis. Transgenic mice deficient in CXCL13 or its receptor CXCR5 have severely impaired lymph node development, lack peritoneal B-lymphocytes and are deficient in circulating antibodies to common bacterial antigens. However, total circulating numbers of B-lymphocytes are slightly elevated and humoral responses to T-dependent or blood-borne antigens are relatively normal. Lymphoid neogenesis is an aberrant process that occurs in chronically inflamed tissue and provides a microenvironment supportive of pathogenic B-cell survival and activation. Here, we describe the impact of therapeutic dosing of a CXCL13 antibody in a mouse model of arthritis, and detail the contribution CXCL13 makes to lymphoid follicle microenvironment, without affecting humoral immune responses.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Modelos Animais de Doenças
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Quimiocina CXCL13
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Tecido Linfoide
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article