Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.

Johnson, Erika Segear; Lindblom, Kelly R; Robeson, Alexander; Stevens, Robert D; Ilkayeva, Olga R; Newgard, Christopher B; Kornbluth, Sally; Andersen, Joshua L

Johnson, Erika Segear; Lindblom, Kelly R; Robeson, Alexander; Stevens, Robert D; Ilkayeva, Olga R; Newgard, Christopher B; Kornbluth, Sally; Andersen, Joshua L.

Afiliação

Johnson ES; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27708.
Lindblom KR; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27708.
Robeson A; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27708.
Stevens RD; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27704; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27708.
Ilkayeva OR; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27704.
Newgard CB; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27708; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27704.
Kornbluth S; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27708. Electronic address: kornb001@mc.duke.edu.
Andersen JL; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27708. Electronic address: jandersen@chem.byu.edu.

J Biol Chem ; 288(20): 14463-14475, 2013 May 17.

Article em En | MEDLINE | ID: mdl-23553630

Assuntos

Apoptose; Caspase 2/metabolismo; Ácidos Graxos/metabolismo; Regulação Enzimológica da Expressão Gênica; Metabolômica/métodos; Ácido Amino-Oxiacético/metabolismo; Animais; Carnitina/análogos & derivados; Carnitina/metabolismo; Morte Celular; Cromatografia em Gel; Ativação Enzimática; Células HEK293; Hepatócitos/citologia; Humanos; Palmitatos/metabolismo; RNA Interferente Pequeno/metabolismo; Xenopus laevis/metabolismo

Palavras-chave

Apoptosis; Caspase; Hepatocyte; Lipids; Metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Apoptose / Caspase 2 / Ácidos Graxos / Metabolômica Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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