Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.
Org Biomol Chem
; 11(25): 4147-53, 2013 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-23715589
ABSTRACT
JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Radiossensibilizantes
/
Compostos de Boro
/
Sequestradores de Radicais Livres
/
Corantes Fluorescentes
/
Mitocôndrias
/
Óxidos de Nitrogênio
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article