Anticardiolipin antibodies and lupus anticoagulants among women undergoing in vitro fertilization in Jamaica.
West Indian Med J
; 61(8): 789-94, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-23757899
ABSTRACT
OBJECTIVE:
The aims of this study were to evaluate the effect of anticardiolipin antibody (aCL) and lupus anticoagulant (LA) on the outcome of the in vitro ferlitization (IVF) cycles and to determine the prevalence of these antibodies in infertile women seeking IVF in Jamaica.METHODS:
A retrospective cohort study was performed to determine if screening patients for aCL and LA had any significant impact on the outcome of the IVF process. Each patients hospital record, between March 2000 and March 2010, was collected and the relevant data extracted.RESULTS:
The prevalence of aCL in this cohort of Jamaican women was moderate/high positive 3.88%, low positive 0.68% and those with negative aCL results 95.4%. The prevalence of women who were LA positive was 4.1% and 0.9% of the women were positive for both LA and aCL. Of the patients who were LA and/or aCL positive, eight out of 30 patients (26.7%) had a positive pregnancy test in comparison to 61 out of 181 patients (33.7%) who were LA and/or aCL negative (p = 0.5787).CONCLUSION:
The prevalence of positive aCL and/or LA in infertile women seeking IVF in Jamaica is 7.76%. The presence of these antibodies did not affect the pregnancy rate of these women nor did it demonstrate an increased risk for IVF cycle cancellation or ovarian hyperstimulation syndrome. Screening women undergoing IVF for these antibodies is not justified.
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Base de dados:
MEDLINE
Assunto principal:
Inibidor de Coagulação do Lúpus
/
Anticorpos Anticardiolipina
/
Infertilidade Feminina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article