An improved cation exchange HPLC method for the measurement of serum creatinine.

ABSTRACT

An improved HPLC method for the measurement of serum creatinine is described. Separation is effected using a strong cation exchange column at pH 4.7. Analytical recovery, precision and linearity are satisfactory, and the method correlates well with a kinetic Jaffé procedure. The method provides a means of accurately measuring creatinine and may be of use in the investigation of interference in creatinine assays.