[Viral and drug-induced liver damage in children with tuberculosis: prevalence, clinical features].

ABSTRACT

UNLABELLED THE AIM OF THE RESEARCH Improving the effectiveness of diagnostics and treatment of viral and drug-induced lesions of the liver (DILL) at a tuberculosis in children by identifying the frequency of their distribution, peculiarities of diagnostics and clinics. MATERIALS AND METHODS: We examined 242 children in the age from 2 months to 17 years, the patients with different forms of tuberculosis. RESULTS: The prevalence of hepatitis in children with tuberculosis B - 1,2%, C-0.4%, G - 4,6%, TT - 8,7%. DILL was diagnosed in 67.5% of children - TB patients, in 48% of the children with DILL an asymptomatic course of the disease was noted, however, in 54.4% of the children with DILL cytolitic syndrome was expressed (ALT> standards). CONCLUSION: The prevalence of viral hepatitis B and C among children with TB is low. The infection with viruses of hepatitis G and TT is more often, but has no significant impact as on the course of tuberculosis, and on the severity of the liver damage. Drug-induced liver damage is a dominant view of pathology of the liver in children - TB patients and is mostly asymptomatic, but with a pronounced cytolitic syndrome.