Diagnostic accuracy of K-ras mutation for pancreatic carcinoma: a meta-analysis.
Hepatobiliary Pancreat Dis Int
; 12(5): 458-64, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24103274
ABSTRACT
BACKGROUND:
The conventional tests for the diagnosis of early stage pancreatic carcinoma are not acceptable. This meta-analysis is to evaluate the accuracy of K-ras mutation for the diagnosis of pancreatic carcinoma. DATA SOURCES A systemic search of all relevant literature was performed in Web of Science, EMBASE, Cochrane Database, and MEDLINE (PubMed as the search engine) prior to June 1, 2011. Thirty-four studies fulfilled the inclusion criteria and data were pooled for analysis.RESULTS:
The pooled estimates for K-ras mutation in diagnosis of pancreatic carcinoma were as follows sensitivity 0.68 (95% CI 0.66-0.71), specificity 0.87 (95% CI 0.85-0.88), positive likelihood ratio 4.54 (95% CI 3.47-5.94), negative likelihood ratio 0.37 (95% CI 0.30-0.44) and diagnostic odds ratio 14.90 (95% CI 10.02-22.15). Summary receiver operating characteristic analysis demonstrated that the maximum joint sensitivity and specificity was 0.79, and the overall area under the curve was 0.86.CONCLUSIONS:
Diagnostic accuracy of K-ras mutation was not superior to that of conventional tests. Therefore, K-ras mutation analysis alone is not recommended for the diagnosis of pancreatic carcinoma.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Análise Mutacional de DNA
/
Carcinoma
/
Biomarcadores Tumorais
/
Testes Genéticos
/
Proteínas Proto-Oncogênicas
/
Proteínas ras
/
Mutação
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article