[Development of (hypo)mania during discontinuation of venlafaxine in two patients with bipolar disorder]. / Een (hypo)manie tijdens de afbouw van venlafaxine bij twee patiënten met een bipolaire stoornis.
Tijdschr Psychiatr
; 55(10): 795-800, 2013.
Article
em Nl
| MEDLINE
| ID: mdl-24166339
ABSTRACT
The scientific literature frequently warns that patients with bipolar disorder risk developing a (hypo)mania on starting a course of antidepressants. In this case report, however, two patients with bipolar disorder developed a (hypo)mania while their dosage of venlafaxine was being gradually tapered off. We discuss a pharmacodynamic explanation for the induction of (hypo)mania during discontinuation of venlafaxine. We also discuss alternative explanations, such as a venlafaxine withdrawal syndrome; induction of rapid cycling; difficulties in distinguishing an agitated depression and a dysphoric mania and the naturalistic course of a bipolar disorder.
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Inibidores Seletivos de Recaptação de Serotonina
/
Cicloexanóis
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
Nl
Ano de publicação:
2013
Tipo de documento:
Article