Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38&#945; modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

Germani, Aldo; Matrone, Antonio; Grossi, Valentina; Peserico, Alessia; Sanese, Paola; Liuzzi, Micaela; Palermo, Rocco; Murzilli, Stefania; Campese, Antonio Francesco; Ingravallo, Giuseppe; Canettieri, Gianluca; Tezil, Tugsan; Simone, Cristiano

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

Germani, Aldo; Matrone, Antonio; Grossi, Valentina; Peserico, Alessia; Sanese, Paola; Liuzzi, Micaela; Palermo, Rocco; Murzilli, Stefania; Campese, Antonio Francesco; Ingravallo, Giuseppe; Canettieri, Gianluca; Tezil, Tugsan; Simone, Cristiano.

Afiliação

Germani A; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy.
Matrone A; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy.
Grossi V; Cancer Genetics Laboratory, IRCCS S. de Bellis, 70013 Castellana Grotte, Italy.
Peserico A; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy.
Sanese P; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy.
Liuzzi M; Division of Pathological Anatomy, DETO, University of Bari, 70124 Bari, Italy.
Palermo R; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Murzilli S; Animal Care Facility, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy.
Campese AF; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Ingravallo G; Division of Pathological Anatomy, DETO, University of Bari, 70124 Bari, Italy.
Canettieri G; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Tezil T; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy. Electronic address: teziltugsan@sabanciuniv.edu.
Simone C; Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy; Division of Medical Genetics, DIMO, University of Bari, 70124 Bari, Italy. Electronic address: cristiano.simone@uniba.it.

Cancer Lett ; 344(1): 110-118, 2014 Mar 01.

Article em En | MEDLINE | ID: mdl-24215867

Assuntos

Neoplasias Colorretais/metabolismo; Resistencia a Medicamentos Antineoplásicos/fisiologia; Fatores de Transcrição Forkhead/metabolismo; Proteína Quinase 14 Ativada por Mitógeno/antagonistas & inibidores; Terapia de Alvo Molecular/métodos; Animais; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular; Cisplatino/farmacologia; Feminino; Citometria de Fluxo; Imunofluorescência; Proteína Forkhead Box O3; Células HT29; Humanos; Immunoblotting; Camundongos; Camundongos Nus; Reação em Cadeia da Polimerase em Tempo Real; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cell death; Chemoresistance; Colorectal cancer; Dual therapy; p38 MAPK

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Resistencia a Medicamentos Antineoplásicos / Proteína Quinase 14 Ativada por Mitógeno / Fatores de Transcrição Forkhead / Terapia de Alvo Molecular Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google