Prostaglandin EP4 antagonists.
Pharm Pat Anal
; 2(3): 387-97, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-24237064
ABSTRACT
Prostaglandin antagonists, with their pharmacological effects, are well-known drugs capable of treating widely diffused illnesses, including pain and inflammation disorders. In recent years, a major research focus has been devoted to the identification of agents able to selectively antagonize each receptor with which prostaglandins interact. This review attempts to give a broad overview of molecules capable of selectively blocking the prostaglandin PGE2 EP4 receptor. Further therapeutic applications and uses have also been disccussed, including the first drug candidate to have reached clinical trials within the last few years.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antagonistas de Prostaglandina
/
Receptores de Prostaglandina E Subtipo EP4
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article