Early outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a European multicenter and multinational study.
Catheter Cardiovasc Interv
; 84(1): 101-7, 2014 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-24285605
ABSTRACT
BACKGROUND:
This study was designed to evaluate the outcomes of alcohol septal ablation (ASA) under multicenter and multinational conditions.METHODS:
Data for 459 patients (age 57 ± 13 years) from nine European centers were prospectively collected and retrospectively analyzed.RESULTS:
ASA led to a significant reduction in outflow gradient (PG) and dyspnea [median of PG from 88 (58-123) mm Hg to 21 (11-41) mm Hg; median of NYHA class from 3 (2-3) to 1 (1-2); P < 0.01]. The incidence of 3-month major adverse events (death, electrical cardioversion for tachyarrhythmias, resuscitation) and mortality was 2.8% and 0.7%, respectively. Permanent pacemakers for post-ASA complete heart block were implanted in 43 patients (9%). Multivariate analysis identified higher amount of alcohol (however, in generally low-dose procedures), higher baseline left ventricular ejection fraction and higher age as independent predictors of PG decrease ≥50%.CONCLUSIONS:
The results of the first European multicenter and multinational study demonstrate that real-world early outcomes of ASA patients are better than was reported in observations from the first decade after ASA introduction.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cardiomiopatia Hipertrófica
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Etanol
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Técnicas de Ablação
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Septos Cardíacos
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Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article