H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge.
J Virol
; 88(4): 2340-3, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24307585
ABSTRACT
The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Infecções por Orthomyxoviridae
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Subtipo H7N9 do Vírus da Influenza A
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article