RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.
EMBO J
; 33(6): 542-58, 2014 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-24514026
ABSTRACT
The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNADNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen-associated molecular patterns sensed by pattern recognition receptors. Here we establish that RNADNA hybrids containing viral-derived sequences efficiently induce pro-inflammatory cytokine and antiviral type I interferon production in dendritic cells. We demonstrate that MyD88-dependent signalling is essential for this cytokine response and identify TLR9 as a specific sensor of RNADNA hybrids. Hybrids therefore represent a novel molecular pattern sensed by the innate immune system and so could play an important role in host response to viruses and the pathogenesis of autoimmune disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Transdução de Sinais
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Modelos Imunológicos
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Receptor Toll-Like 9
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Imunidade Inata
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Ácidos Nucleicos Heteroduplexes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article