Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.
J Virol
; 88(9): 5165-70, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24554654
ABSTRACT
Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Anti-HIV
/
HIV-1
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Produtos do Gene env do Vírus da Imunodeficiência Humana
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Especificidade de Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article