Quality control: ER-associated degradation: protein quality control and beyond.
J Cell Biol
; 204(6): 869-79, 2014 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-24637321
ABSTRACT
Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up misfolded. Cells evolved protein quality control systems to ensure that these potentially toxic species are detected and eliminated. The best characterized of these pathways, the ER-associated protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the endoplasmic reticulum (ER). There is also increasing evidence that ERAD controls other ER-related functions through regulated degradation of certain folded ER proteins, further highlighting the role of ERAD in cellular homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Degradação Associada com o Retículo Endoplasmático
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article