Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid.
Int J Cosmet Sci
; 36(3): 253-61, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24697191
ABSTRACT
In this study, we developed an organoculture of human skin to investigate the effect of topical applied all-trans retinoic acid using a gene array approach. We could by using this approach confirm previous studies on genes activated by RA in keratinocyte monocultures and also provide new insights on genes that are relevant to RA-activation in human skin. The results in the present study show this model represent a valuable pre-clinical model for studying the effects of retinoids in skin.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Fenômenos Fisiológicos da Pele
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Tretinoína
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Regulação da Expressão Gênica
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article