Localization and purification of SBU-4--a pregnancy specific protein of the ovine uterus.
Placenta
; 10(1): 71-82, 1989.
Article
em En
| MEDLINE
| ID: mdl-2470078
ABSTRACT
In order to elucidate the function of molecules of the ovine maternal-fetal interface a monoclonal antibody was produced to intact interplacentomal trophoblast membranes. Extensive immunohistological studies revealed that the monoclonal antibody recognizes a protein designated SBU-4 which originates in the intercaruncular regions of the gravid sheep uterus at about the time of implantation and increases in concentration throughout gestation. The data suggest that SBU-4 is produced by endometrial epithelial cells and that adjacent uninucleate cells of the trophoblast acquire the antigen by endocytosis. Initial biochemical analysis of the purified SBU-4 molecule prepared by monoclonal antibody immunoaffinity chromatography indicates that SBU-4 is high molecular weight glycoprotein complex comprising several sub-units.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas da Gravidez
/
Útero
/
Ovinos
/
Antígenos de Histocompatibilidade Classe I
/
Antígenos de Histocompatibilidade
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article