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Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
Buczkowicz, Pawel; Hoeman, Christine; Rakopoulos, Patricia; Pajovic, Sanja; Letourneau, Louis; Dzamba, Misko; Morrison, Andrew; Lewis, Peter; Bouffet, Eric; Bartels, Ute; Zuccaro, Jennifer; Agnihotri, Sameer; Ryall, Scott; Barszczyk, Mark; Chornenkyy, Yevgen; Bourgey, Mathieu; Bourque, Guillaume; Montpetit, Alexandre; Cordero, Francisco; Castelo-Branco, Pedro; Mangerel, Joshua; Tabori, Uri; Ho, King Ching; Huang, Annie; Taylor, Kathryn R; Mackay, Alan; Bendel, Anne E; Nazarian, Javad; Fangusaro, Jason R; Karajannis, Matthias A; Zagzag, David; Foreman, Nicholas K; Donson, Andrew; Hegert, Julia V; Smith, Amy; Chan, Jennifer; Lafay-Cousin, Lucy; Dunn, Sandra; Hukin, Juliette; Dunham, Chris; Scheinemann, Katrin; Michaud, Jean; Zelcer, Shayna; Ramsay, David; Cain, Jason; Brennan, Cameron; Souweidane, Mark M; Jones, Chris; Allis, C David; Brudno, Michael.
Afiliação
  • Buczkowicz P; 1] Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. [2] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Department of Laboratory Medicine and Pathobiology, Faculty of Medicine,
  • Hoeman C; 1] Division of Pediatric Hematology/Oncology, Duke University Medical Center, Durham, North Carolina, USA. [2].
  • Rakopoulos P; 1] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Pajovic S; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Letourneau L; Génome Québec Innovation Centre, McGill University, Montreal, Quebec, Canada.
  • Dzamba M; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
  • Morrison A; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Lewis P; Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, New York, USA.
  • Bouffet E; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Bartels U; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Zuccaro J; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Agnihotri S; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ryall S; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Barszczyk M; 1] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Chornenkyy Y; 1] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Bourgey M; Génome Québec Innovation Centre, McGill University, Montreal, Quebec, Canada.
  • Bourque G; Génome Québec Innovation Centre, McGill University, Montreal, Quebec, Canada.
  • Montpetit A; Génome Québec Innovation Centre, McGill University, Montreal, Quebec, Canada.
  • Cordero F; Division of Pediatric Hematology/Oncology, Duke University Medical Center, Durham, North Carolina, USA.
  • Castelo-Branco P; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Mangerel J; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Tabori U; 1] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ho KC; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Huang A; 1] Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Taylor KR; Division of Cancer Therapeutics, Institute of Cancer Research, London, UK.
  • Mackay A; Division of Cancer Therapeutics, Institute of Cancer Research, London, UK.
  • Bendel AE; Department of Pediatric Hematology-Oncology, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, USA.
  • Nazarian J; Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA.
  • Fangusaro JR; Department of Pediatrics-Hematology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
  • Karajannis MA; Division of Pediatric Hematology/Oncology and Neuropathology, New York University Cancer Institute, New York University Langone Medical Center, New York, New York, USA.
  • Zagzag D; Division of Pediatric Hematology/Oncology and Neuropathology, New York University Cancer Institute, New York University Langone Medical Center, New York, New York, USA.
  • Foreman NK; Department of Pediatrics, Children's Hospital Colorado, Denver, Colorado, USA.
  • Donson A; Department of Pediatrics, Children's Hospital Colorado, Denver, Colorado, USA.
  • Hegert JV; Department of Pathology, Arnold Palmer Hospital for Children, Orlando, Florida, USA.
  • Smith A; Department of Pathology, Arnold Palmer Hospital for Children, Orlando, Florida, USA.
  • Chan J; Clark H. Smith Brain Tumour Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Lafay-Cousin L; Clark H. Smith Brain Tumour Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Dunn S; Department of Pediatric Neurology and Neuro-Oncology, BC Children's Hospital, Vancouver, British Columbia, Canada.
  • Hukin J; Department of Pediatric Neurology and Neuro-Oncology, BC Children's Hospital, Vancouver, British Columbia, Canada.
  • Dunham C; Department of Pediatric Neurology and Neuro-Oncology, BC Children's Hospital, Vancouver, British Columbia, Canada.
  • Scheinemann K; Division of Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
  • Michaud J; Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
  • Zelcer S; Department of Hematology/Oncology, Children's Hospital London Health Sciences Centre, London, Ontario, Canada.
  • Ramsay D; Department of Hematology/Oncology, Children's Hospital London Health Sciences Centre, London, Ontario, Canada.
  • Cain J; Monash Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia.
  • Brennan C; Department of Neurological Surgery, Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Souweidane MM; Department of Neurological Surgery, Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Jones C; Division of Cancer Therapeutics, Institute of Cancer Research, London, UK.
  • Allis CD; Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, New York, USA.
  • Brudno M; 1] Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. [2] The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nat Genet ; 46(5): 451-6, 2014 May.
Article em En | MEDLINE | ID: mdl-24705254
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Genoma Humano / Neoplasias do Tronco Encefálico / Receptores de Ativinas Tipo I / Glioma Limite: Animals / Child / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Genoma Humano / Neoplasias do Tronco Encefálico / Receptores de Ativinas Tipo I / Glioma Limite: Animals / Child / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article