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Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging.
Salphati, Laurent; Shahidi-Latham, Sheerin; Quiason, Cristine; Barck, Kai; Nishimura, Merry; Alicke, Bruno; Pang, Jodie; Carano, Richard A; Olivero, Alan G; Phillips, Heidi S.
Afiliação
  • Salphati L; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California salphati.laurent@gene.com.
  • Shahidi-Latham S; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Quiason C; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Barck K; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Nishimura M; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Alicke B; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Pang J; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Carano RA; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Olivero AG; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
  • Phillips HS; Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.
Drug Metab Dispos ; 42(7): 1110-6, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24754926
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Tiofenos / Neoplasias Encefálicas / Glioblastoma / Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Inibidores Enzimáticos / Inibidores de Fosfoinositídeo-3 Quinase / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Tiofenos / Neoplasias Encefálicas / Glioblastoma / Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Inibidores Enzimáticos / Inibidores de Fosfoinositídeo-3 Quinase / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article