The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.
J Exp Med
; 170(5): 1787-92, 1989 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-2478657
ABSTRACT
IgE-independent mediator release from basophils is considered an important event in inflammation, particularly in nonallergic immediate hypersensitivity and in allergic late-phase reactions. This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1. Thus, the sequential action of two pure cytokines can promote basophils mediator release. In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Basófilos
/
SRS-A
/
Interleucina-3
/
Liberação de Histamina
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article