Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

Man, Si Ming; Hopkins, Lee J; Nugent, Eileen; Cox, Susan; Glück, Ivo M; Tourlomousis, Panagiotis; Wright, John A; Cicuta, Pietro; Monie, Tom P; Bryant, Clare E

Man, Si Ming; Hopkins, Lee J; Nugent, Eileen; Cox, Susan; Glück, Ivo M; Tourlomousis, Panagiotis; Wright, John A; Cicuta, Pietro; Monie, Tom P; Bryant, Clare E.

Afiliação

Man SM; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;
Hopkins LJ; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;
Nugent E; Sector of Biological and Soft Systems, The Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, United Kingdom;
Cox S; Randall Division of Cell and Molecular Biophysics, Kings College, London WC2R 2LS, United Kingdom; and.
Glück IM; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;
Tourlomousis P; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;
Wright JA; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom;
Cicuta P; Sector of Biological and Soft Systems, The Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, United Kingdom;
Monie TP; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Bryant CE; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom; ceb27@cam.ac.uk.

Proc Natl Acad Sci U S A ; 111(20): 7403-8, 2014 May 20.

Article em En | MEDLINE | ID: mdl-24803432

Assuntos

Proteínas Reguladoras de Apoptose/metabolismo; Células da Medula Óssea/microbiologia; Proteínas de Ligação ao Cálcio/metabolismo; Proteínas de Transporte/metabolismo; Caspase 1/metabolismo; Caspase 8/metabolismo; Inflamassomos/fisiologia; Macrófagos/microbiologia; Animais; Apoptose; Ativação Enzimática; Células HEK293; Humanos; Inflamação; Interleucina-1beta/metabolismo; Camundongos; Camundongos Transgênicos; Proteína 3 que Contém Domínio de Pirina da Família NLR; Salmonella typhimurium

Palavras-chave

ASC; bacteria; caspase-1; caspase-8; innate immunity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Células da Medula Óssea / Proteínas de Transporte / Caspase 1 / Proteínas Reguladoras de Apoptose / Caspase 8 / Inflamassomos / Macrófagos Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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