Rho-GTPases as key regulators of T lymphocyte biology.
Small GTPases
; 52014.
Article
em En
| MEDLINE
| ID: mdl-24825161
ABSTRACT
Rho-GTPases belong to the Ras superfamily and are crucial signal transducing proteins downstream of many receptors. In general, the Rho-GTPases function as molecular switches, cycling between inactive (GDP-bound) and active (GTP-bound) states. The activated GTP bound Rho-GTPases interact with a broad spectrum of effectors to regulate a plethora of biological pathways including cytoskeletal dynamics, motility, cytokinesis, cell growth, apoptosis, transcriptional activity and nuclear signaling. Recently, gene targeting in mice allowed the selective inactivation of different Rho-GTPases and has advanced our understanding of the physiological role of these proteins, particularly in the immune system. Particularly, these proteins are key signaling molecules in T lymphocytes, which are generated in the thymus and are major players in the immune system. The scope of this review is to discuss recent data obtained in Rho-GTPases deficient mice by focusing on the role-played by Rho-GTPases in T-lymphocyte development, migration, activation and differentiation.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Proteínas rho de Ligação ao GTP
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article