The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity.
Bioorg Med Chem Lett
; 24(13): 2815-9, 2014 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-24835628
ABSTRACT
We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the natural product. The retention of activity in an analogue lacking the enone functional group, 9, implies this structural element is not an essential part of the (+)-grandifloracin pharmacophore.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hidrocarbonetos Aromáticos com Pontes
/
Cetonas
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article