Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.

Liu, Ping; Lanza, Thomas J; Chioda, Marc; Jones, Carrie; Chobanian, Harry R; Guo, Yan; Chang, Linda; Kelly, Theresa M; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J; Metzger, Joseph M; Ramsay, Katie; Wang, Sheng-Ping; Strack, Alison M; Miller, Randy; Pang, Jianmei; Lyons, Kathy; Dragovic, Jasminka; Ning, Jian G; Schafer, Wes A; Welch, Christopher J; Gong, Xiaoyi; Gao, Ying-Duo; Hornak, Viktor; Ball, Richard G; Tsou, Nancy; Reitman, Marc L; Wyvratt, Matthew J; Nargund, Ravi P; Lin, Linus S

Liu, Ping; Lanza, Thomas J; Chioda, Marc; Jones, Carrie; Chobanian, Harry R; Guo, Yan; Chang, Linda; Kelly, Theresa M; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J; Metzger, Joseph M; Ramsay, Katie; Wang, Sheng-Ping; Strack, Alison M; Miller, Randy; Pang, Jianmei; Lyons, Kathy; Dragovic, Jasminka; Ning, Jian G; Schafer, Wes A; Welch, Christopher J; Gong, Xiaoyi; Gao, Ying-Duo; Hornak, Viktor; Ball, Richard G; Tsou, Nancy; Reitman, Marc L; Wyvratt, Matthew J; Nargund, Ravi P; Lin, Linus S.

Afiliação

Liu P; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Lanza TJ; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Chioda M; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Jones C; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Chobanian HR; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Guo Y; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Chang L; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Kelly TM; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Kan Y; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Palyha O; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Guan XM; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Marsh DJ; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Metzger JM; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ramsay K; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Wang SP; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Strack AM; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Miller R; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Pang J; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Lyons K; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Dragovic J; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ning JG; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Schafer WA; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Welch CJ; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Gong X; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Gao YD; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Hornak V; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ball RG; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Tsou N; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Reitman ML; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Wyvratt MJ; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Nargund RP; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Lin LS; Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, Drug Metabolism, Analytic Chemistry, Chemistry Modeling & Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.