Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function.

Riches, Kirsten; Alshanwani, Aliah R; Warburton, Philip; O'Regan, David J; Ball, Stephen G; Wood, Ian C; Turner, Neil A; Porter, Karen E

Riches, Kirsten; Alshanwani, Aliah R; Warburton, Philip; O'Regan, David J; Ball, Stephen G; Wood, Ian C; Turner, Neil A; Porter, Karen E.

Afiliação

Riches K; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK.
Alshanwani AR; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK.
Warburton P; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK.
O'Regan DJ; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK; Department of Cardiac Surgery, The Yorkshire Heart Centre, Leeds General Infirmary, Leeds, UK.
Ball SG; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK.
Wood IC; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Turner NA; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK.
Porter KE; Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK; Multidisciplinary Cardiovascular Research Centre (MCRC), University of Leeds, Leeds, UK. Electronic address: medkep@leeds.ac.uk.

J Mol Cell Cardiol ; 74: 240-50, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24927876

Assuntos

Diabetes Mellitus Tipo 2/genética; MicroRNAs/genética; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/metabolismo; Veia Safena/metabolismo; Actinas/genética; Actinas/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/patologia; Feminino; Regulação da Expressão Gênica; Glucose/metabolismo; Glucose/farmacologia; Humanos; Hipoglicemiantes/uso terapêutico; Interleucina-1alfa/farmacologia; Fator 4 Semelhante a Kruppel; Fatores de Transcrição Kruppel-Like/genética; Fatores de Transcrição Kruppel-Like/metabolismo; Masculino; MicroRNAs/metabolismo; Pessoa de Meia-Idade; Músculo Liso Vascular/efeitos dos fármacos; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/patologia; Cadeias Pesadas de Miosina/genética; Cadeias Pesadas de Miosina/metabolismo; Fenótipo; Cultura Primária de Células; Veia Safena/efeitos dos fármacos; Veia Safena/patologia; Fator de Crescimento Transformador beta/farmacologia; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

TGFß; Type 2 diabetes; differentiation; microRNA-143/145; smooth muscle cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veia Safena / Miócitos de Músculo Liso / MicroRNAs / Diabetes Mellitus Tipo 2 / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Aged80 Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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