Keteniminium ion-initiated cascade cationic polycyclization.
J Am Chem Soc
; 136(36): 12528-31, 2014 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-24931745
ABSTRACT
A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to three contiguous stereocenters and seven fused cycles. These complex, polycyclic molecules can be obtained in a single operation from readily available ynamides which were shown to be remarkable building blocks for multiple, consecutive cationic transformations.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2014
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Article