A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.
J Exp Med
; 211(7): 1363-77, 2014 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-24935257
ABSTRACT
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immunodeficient mice against CD1c(+) human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
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Lisofosfolipídeos
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Glicoproteínas
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Linfócitos T
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Leucemia Mieloide Aguda
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Crise Blástica
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Antígenos CD1
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Vigilância Imunológica
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Animals
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article