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7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
D'Erasmo, Michael P; Smith, William B; Munoz, Alberto; Mohandas, Poornima; Au, Andrew S; Marineau, Jason J; Quadri, Luis E N; Bradner, James E; Murelli, Ryan P.
Afiliação
  • D'Erasmo MP; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Smith WB; Department of Medical Oncology, Dayna-Farber Cancer Institute, Boston, MA 02215, United States.
  • Munoz A; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States.
  • Mohandas P; Department of Biology, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Biology, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Au AS; Department of Biology, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States.
  • Marineau JJ; Department of Medical Oncology, Dayna-Farber Cancer Institute, Boston, MA 02215, United States.
  • Quadri LE; Department of Biology, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Biology, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Bradner JE; Department of Medical Oncology, Dayna-Farber Cancer Institute, Boston, MA 02215, United States; Department of Medicine, Harvard Medical School, Boston, MA 02215, United States.
  • Murelli RP; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States. Electronic address: rpmurelli@brookl
Bioorg Med Chem Lett ; 24(16): 4035-8, 2014 Aug 15.
Article em En | MEDLINE | ID: mdl-25011911
ABSTRACT
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article