Facile access to amides and hydroxamic acids directly from nitroarenes.
Org Biomol Chem
; 12(33): 6465-9, 2014 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-25019340
ABSTRACT
A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid whereas reaction in the presence of 1 mmol acetic acid produced amides as the only product.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Amidas
/
Ácidos Hidroxâmicos
/
Nitrobenzenos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article