Transporter taxonomy - a comparison of different transport protein classification schemes.
Drug Discov Today Technol
; 12: e37-46, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-25027374
ABSTRACT
Currently, there are more than 800 well characterized human membrane transport proteins (including channels and transporters) and there are estimates that about 10% (approx. 2000) of all human genes are related to transport. Membrane transport proteins are of interest as potential drug targets, for drug delivery, and as a cause of side effects and drugdrug interactions. In light of the development of Open PHACTS, which provides an open pharmacological space, we analyzed selected membrane transport protein classification schemes (Transporter Classification Database, ChEMBL, IUPHAR/BPS Guide to Pharmacology, and Gene Ontology) for their ability to serve as a basis for pharmacology driven protein classification. A comparison of these membrane transport protein classification schemes by using a set of clinically relevant transporters as use-case reveals the strengths and weaknesses of the different taxonomy approaches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Bases de Dados de Proteínas
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Bases de Dados de Produtos Farmacêuticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article