Stereoselective acylation of the E,E-vinylketene silyl N,O-acetal and its application to the synthesis of khafrefungin.
Org Lett
; 16(16): 4106-9, 2014 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-25072267
ABSTRACT
Stereoselective acylation of the E,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved by using acid anhydrides and SnCl4. Acid anhydrides having alkyl chains gave the adducts in excellent stereoselectivity. The formal synthesis of khafrefungin has been accomplished by the methodology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Silanos
/
Glicolipídeos
/
Acetais
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article