Galleria mellonella as an infection model for select agents.
Methods Mol Biol
; 1197: 3-9, 2014.
Article
em En
| MEDLINE
| ID: mdl-25172272
ABSTRACT
The use of animal models is a key step to better understand bacterial virulence factors and their roles in host/pathogen interactions. To avoid the ethical and cost problems of mammalian models in bacterial virulence research, several insect models have been developed. One of these models, the larvae of the greater wax moth Galleria mellonella, has been shown to be relevant for several fungal and bacterial mammalian pathogens. Here, we describe the use G. mellonella to study virulence of the highly virulent facultative intracellular bacterial pathogens Brucella suis, Brucella melitensis, Francisella tularensis, Burkholderia mallei, and Burkholderia pseudomallei.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
/
Mariposas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article