Nymphaea rubra ameliorates TNF-α-induced insulin resistance via suppression of c-Jun NH2-terminal kinase and nuclear factor-κB in the rat skeletal muscle cells.
Appl Biochem Biotechnol
; 174(7): 2446-57, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25234391
In this work, we demonstrated insulin signaling and the anti-inflammatory effects by the chloroform fraction of ethanolic extract of Nymphaea rubra flowers in TNF-α-induced insulin resistance in the rat skeletal muscle cell line (L6 myotubes) to dissect out its anti-hyperglycemic mechanism. N. rubra enhances the GLUT4-mediated glucose transport in a dose dependent manner and also increases the tyrosine phosphorylation of both IR-ß and IRS-1, and the IRS-1 associated PI-3 kinase activity in TNF-α-treated L6 myotubes. Moreover, N. rubra decreases Ser(307) phosphorylation of IRS-1 by the suppression of JNK and NF-κB activation. In conclusion, N. rubra reverses the insulin resistance by the inhibition of c-Jun NH2-Terminal Kinase and Nuclear-κB.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
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Extratos Vegetais
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NF-kappa B
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Fator de Necrose Tumoral alfa
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Fibras Musculares Esqueléticas
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Nymphaea
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Flores
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Proteínas Quinases JNK Ativadas por Mitógeno
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Hipoglicemiantes
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article