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Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid ß-peptides (Aß) by γ-secretase to increase 42-to-40-residue Aß.
Fernandez, Marty A; Klutkowski, Julia A; Freret, Taylor; Wolfe, Michael S.
Afiliação
  • Fernandez MA; From the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
  • Klutkowski JA; From the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
  • Freret T; From the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
  • Wolfe MS; From the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115 mwolfe@partners.org.
J Biol Chem ; 289(45): 31043-52, 2014 Nov 07.
Article em En | MEDLINE | ID: mdl-25239621
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Presenilina-1 / Doença de Alzheimer / Mutação Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Presenilina-1 / Doença de Alzheimer / Mutação Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article