Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design.

Blair, Jessica M A; Smith, Helen E; Ricci, Vito; Lawler, Amelia J; Thompson, Louisa J; Piddock, Laura J V

Blair, Jessica M A; Smith, Helen E; Ricci, Vito; Lawler, Amelia J; Thompson, Louisa J; Piddock, Laura J V.

Afiliação

Blair JM; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK.
Smith HE; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK.
Ricci V; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK.
Lawler AJ; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK.
Thompson LJ; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK.
Piddock LJ; Antimicrobials Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, and Institute of Microbiology and Infection, The University of Birmingham, Birmingham B15 2TT, UK l.j.v.piddock@bham.ac.uk.

J Antimicrob Chemother ; 70(2): 424-31, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25288678

Assuntos

Farmacorresistência Bacteriana Múltipla/genética; Regulação Bacteriana da Expressão Gênica; Proteínas de Membrana Transportadoras/genética; Antibacterianos/farmacologia; Relação Dose-Resposta a Droga; Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos; Perfilação da Expressão Gênica; Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos; Inativação Gênica; Genótipo; Testes de Sensibilidade Microbiana; Família Multigênica; Mutação; Salmonella typhimurium/efeitos dos fármacos; Salmonella typhimurium/genética; Virulência/genética

Palavras-chave

AcrB; AcrD; AcrF; redundancy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Regulação Bacteriana da Expressão Gênica / Farmacorresistência Bacteriana Múltipla Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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