CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment.

Wang, Shih-Wei; Liu, Shih-Chia; Sun, Hui-Lung; Huang, Te-Yang; Chan, Chia-Han; Yang, Chen-Yu; Yeh, Hung-I; Huang, Yuan-Li; Chou, Wen-Yi; Lin, Yu-Min; Tang, Chih-Hsin

Wang, Shih-Wei; Liu, Shih-Chia; Sun, Hui-Lung; Huang, Te-Yang; Chan, Chia-Han; Yang, Chen-Yu; Yeh, Hung-I; Huang, Yuan-Li; Chou, Wen-Yi; Lin, Yu-Min; Tang, Chih-Hsin.

Afiliação

Wang SW; Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
Liu SC; Department of Orthopaedics, Mackay Memorial Hospital, Taipei 104, Taiwan.
Sun HL; Department of Molecular Virology, Immunology and Medical Genetics, Ohio state University, Columbus, OH 43210, USA.
Huang TY; Department of Orthopaedics, Mackay Memorial Hospital, Taipei 104, Taiwan.
Chan CH; Department of Orthopaedics, Mackay Memorial Hospital, Taipei 104, Taiwan.
Yang CY; Department of Orthopaedics, Mackay Memorial Hospital, Taipei 104, Taiwan.
Yeh HI; Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
Huang YL; Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan.
Chou WY; Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital Medical Center, Kaohsiung 833, Taiwan.
Lin YM; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, Department of Orthopedic Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan, chtang@mail.cmu.edu.tw ymlin@vghtc.gov.tw.
Tang CH; Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan and Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan chtang@mail.cm

Carcinogenesis ; 36(1): 104-14, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25330803

Assuntos

Neoplasias Ósseas/irrigação sanguínea; Quimiocina CCL5/metabolismo; Neovascularização Patológica/metabolismo; Osteossarcoma/irrigação sanguínea; Receptores CCR5/metabolismo; Microambiente Tumoral; Fator A de Crescimento do Endotélio Vascular/metabolismo; Animais; Western Blotting; Neoplasias Ósseas/metabolismo; Neoplasias Ósseas/patologia; Movimento Celular; Proliferação de Células; Quimiocina CCL5/antagonistas & inibidores; Quimiocina CCL5/genética; Embrião de Galinha; Membrana Corioalantoide/metabolismo; Membrana Corioalantoide/patologia; Imunoprecipitação da Cromatina; Meios de Cultivo Condicionados/farmacologia; Citometria de Fluxo; Humanos; Técnicas Imunoenzimáticas; Masculino; Camundongos; Camundongos Nus; Osteossarcoma/metabolismo; Osteossarcoma/patologia; RNA Mensageiro/genética; RNA Interferente Pequeno/genética; Reação em Cadeia da Polimerase em Tempo Real; Receptores CCR5/química; Receptores CCR5/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Análise Serial de Tecidos; Células Tumorais Cultivadas; Fator A de Crescimento do Endotélio Vascular/genética; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Quimiocina CCL5 / Receptores CCR5 / Fator A de Crescimento do Endotélio Vascular / Microambiente Tumoral / Neovascularização Patológica Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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