Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic &#945;-cell by lowering cAMP.

Elliott, Amicia D; Ustione, Alessandro; Piston, David W

Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.

Elliott, Amicia D; Ustione, Alessandro; Piston, David W.

Afiliação

Elliott AD; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Ustione A; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.
Piston DW; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee dave.piston@vanderbilt.edu.

Am J Physiol Endocrinol Metab ; 308(2): E130-43, 2015 Jan 15.

Article em En | MEDLINE | ID: mdl-25406263

Assuntos

Células Secretoras de Glucagon/metabolismo; Glucagon/metabolismo; Glucose/metabolismo; Insulina/metabolismo; Ilhotas Pancreáticas/metabolismo; Somatostatina/farmacologia; Animais; AMP Cíclico/análise; AMP Cíclico/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Citometria de Fluxo; Humanos; Ilhotas Pancreáticas/citologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microscopia Confocal; Transdução de Sinais/fisiologia

Palavras-chave

cyclic AMP; glucagon; insulin; pancreatic islets; somatostatin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucagon / Somatostatina / Ilhotas Pancreáticas / Células Secretoras de Glucagon / Glucose / Insulina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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