Jorge Lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions.
Mycopathologia
; 179(3-4): 269-74, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25487975
ABSTRACT
BACKGROUND:
Jorge Lobo's disease (JLD) is a cutaneous chronic mycosis caused by Lacazia loboi. We studied Factor XIIIa + dermal dendrocytes (FXIIIa + DD), Langerhans cells (LC) through the expression of langerin and the expression of S100 protein.METHODS:
A total of 41 biopsies and 10 normal skins (control) were developed with a polymer-based immunohistochemical method.RESULTS:
Lesions presented infiltrate comprising macrophages, some asteroid corpuscles, lymphocytes, multinucleated giant cells and a large number of fungi. LCs presented short dendrites and were scarcely distributed. Dermal langerin + cells were detected in nine JLD lesions. FXIIIa + DD were hypertrophic, visualized in the inflammatory infiltrate of JLD lesions. Cells S100+ were present in JLD and control group with a similar number of cells. A total of 14 specimens did not express FXIIIa, and this considerable number probably contributed to the statistical similarity with the control group.CONCLUSIONS:
The results indicate that LCs are present in the immune response against Lacazia loboi. Some dermal langerin + cells could be another subset of dendritic cells. Our data indicate changes of LCs in JLD cutaneous lesions and present, for the first time, results that show langerin + cells in the dermis and corroborate previous observations on the participation of FXIIIa + DD in the in situ immune response in JLD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células de Langerhans
/
Lobomicose
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article