Actomyosin bundles serve as a tension sensor and a platform for ERK activation.
EMBO Rep
; 16(2): 250-7, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25550404
ABSTRACT
Tensile forces generated by stress fibers drive signal transduction events at focal adhesions. Here, we report that stress fibers per se act as a platform for tension-induced activation of biochemical signals. The MAP kinase, ERK is activated on stress fibers in a myosin II-dependent manner. In myosin II-inhibited cells, uniaxial stretching of cell adhesion substrates restores ERK activation on stress fibers. By quantifying myosin II- or mechanical stretch-mediated tensile forces in individual stress fibers, we show that ERK activation on stress fibers correlates positively with tensile forces acting on the fibers, indicating stress fibers as a tension sensor in ERK activation. Myosin II-dependent ERK activation is also observed on actomyosin bundles connecting E-cadherin clusters, thus suggesting that actomyosin bundles, in general, work as a platform for tension-dependent ERK activation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Actomiosina
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Fibras de Estresse
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MAP Quinases Reguladas por Sinal Extracelular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article